The COVID-19 pandemic has brought to the forefront the role of sharing quality data in a timely manner to inform crisis management, public health and research. Moreover, the value of data is enhanced when countries cooperate and facilitate cross-border data flows. Policymakers should harness the value of health data and engage in a global discussion that strives for common, cross-border and effective digital health solutions to improve health outcomes for all. This policy brief argues for action in three key areas: establishing technical and legal building blocks, gaining end users’ trust, and fostering research, innovation and competition.