Mobility is a constantly evolving field. Until today, the success of Global Cities around the world was highly dependent on the efficiency of their infrastructures, as well as on their ability to maintain them. However, over the last two years, the coronavirus pandemic seized control of our lives, leading to substantial social and economic changes. Even if it is still unclear whether these huge transformations will be long-lasting or will fade in time, Covid-19 has undoubtedly changed the world as we knew it. Consequently, nowadays urban mobility’s evolution will depend on new factors, like the post-pandemic adoption of home-office. Which is the contribution of “smart mobility” to the competitiveness of a country – and of its cities – within the new global context? What is the bond between big urban areas and the central government? What will be the role of Global Cities in achieving the Goals of the Agenda 2030? What can we learn from the current best practices?