The G20 Summit is at the starting line with G20 Leaders gathering in Rome on 30-31 October. The agenda of the Summit is loaded with pressing global challenges: vaccinations and access to healthcare, economic recovery and inequalities, climate change and green transition, trade, finance and digitalisation. But the G20 is a year-long multilateral effort. What has already been achieved during the Italian Presidency? What remains to be done and which contribution from the Think20, chaired by ISPI, to face these global challenges? Which legacy for future G20 Presidencies?